Finding recent evidence on the effectiveness of disease treatments can be effortful. The Clinical Knowledge Summary app uses sophisticated machine learning algorithms to search for high quality systematic reviews and clinical trials in PubMed. Users can filter results by treatment, diseases, publication date range, and patient-specific parameters. Just type in a disease or medication name (or a combination of either) and let the app do the searching for you. The app provides "typeahead" functionality with terms extracted from a controlled vocabulary (MeSH).